Vinculin



Vinculins (VCLs) are involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to talin or to alpha-actinin at their respective VCL Binding Sites (VBS). A splice variant of vinculin is meta-vinculin (m-VCL). The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL. The images at the left and at the right correspond to one representative Vinculin structure, i.e. crystal structure of human full-length Vinculin (1tr2).

3D Structures of Vinculin
Update June 2011

3h2u – hVCL Vd1 + raver1 RRM - human

3h2v - hVCL C-terminal + raver1 RRM

2ibf, 2hsq, 2gww - hVCL Vd1 + SfVCL binding sites from Shigella flexneri

1tr2 – hVCL

1ydi - hVCL Vd1+hActinin VBS

1t01 - cVCL Vd1+mTalin VBS – chicken

1syq, 1rkc, 1rke – hVCL Vd1+hTalin VBS

1qkr – hVCL C-terminal

Metavinculin
3myi – m-VCL tail domain

3rf3 - hm-VCL + invasin IPAA

2gdc – cm-VCL Vd1+SfInvasin C-terminal

1xwj - cm-VCL Vd1+cTalin VBS3

1zvz, 1zw2, 1zw3, 1u6h - cm-VCL Vd1+cTalin rod

1st6 – cm-VCL